pI: 4.931 |
Length (AA): 262 |
MW (Da): 30274 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
12 | 97 | 1x4t (A) | 3 | 88 | 57.00 | 0 | 1 | 1.08804 | -0.96 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128335)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G18790 | pre-mRNA-splicing factor ISY1 domain-containing protein |
Babesia bovis | BBOV_III011510 | isy1-like splicing family protein |
Brugia malayi | Bm1_57635 | Isy1-like splicing family protein |
Candida albicans | CaO19.6685 | similar to component of PRP19 complex, pre-mRNA splicing |
Candida albicans | CaO19.13977 | similar to component of PRP19 complex, pre-mRNA splicing |
Candida albicans | CaO19_6685 | hypothetical protein |
Caenorhabditis elegans | CELE_F53B7.3 | Protein F53B7.3 |
Cryptosporidium hominis | Chro.50203 | hypothetical protein |
Cryptosporidium parvum | cgd5_1790 | conserved eukaryotic protein |
Dictyostelium discoideum | DDB_G0285521 | ISY1-like protein |
Drosophila melanogaster | Dmel_CG9667 | CG9667 gene product from transcript CG9667-RA |
Echinococcus granulosus | EgrG_000551900 | pre mRNA splicing factor ISY1 |
Entamoeba histolytica | EHI_187260 | cell cycle control protein cwf12, putative |
Echinococcus multilocularis | EmuJ_000551900 | pre mRNA splicing factor ISY1 |
Homo sapiens | ENSG00000261796 | ISY1-RAB43 readthrough |
Homo sapiens | ENSG00000240682 | ISY1 splicing factor homolog (S. cerevisiae) |
Leishmania braziliensis | LbrM.07.0020 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_070020.1 | Isy1-like splicing family, putative |
Leishmania infantum | LinJ.07.0020 | hypothetical protein, conserved |
Leishmania major | LmjF.07.0020 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.07.0020 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_03439 | hypothetical protein |
Mus musculus | ENSMUSG00000030056 | ISY1 splicing factor homolog (S. cerevisiae) |
Neospora caninum | NCLIV_021210 | isy1-like splicing family domain-containing protein, putative |
Oryza sativa | 4329902 | Os02g0602500 |
Onchocerca volvulus | OVOC6223 | Rab43 protein homolog |
Plasmodium berghei | PBANKA_1335200 | pre-mRNA-splicing factor ISY1, putative |
Plasmodium falciparum | PF3D7_1472000 | pre-mRNA-splicing factor ISY1, putative |
Plasmodium knowlesi | PKNH_1209000 | pre-mRNA-splicing factor ISY1, putative |
Plasmodium vivax | PVX_116880 | pre-mRNA-splicing factor ISY1, putative |
Plasmodium yoelii | PY05359 | hypothetical protein |
Saccharomyces cerevisiae | YJR050W | Isy1p |
Schistosoma japonicum | Sjp_0058660 | Pre-mRNA-splicing factor ISY1 homolog, putative |
Schistosoma japonicum | Sjp_0058600 | IPR011008,Dimeric alpha-beta barrel,domain-containing |
Schistosoma mansoni | Smp_126720 | hypothetical protein |
Schmidtea mediterranea | mk4.000028.07 | |
Trypanosoma brucei gambiense | Tbg972.8.1570 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.8.1930 | Isy1-like splicing family, putative |
Trypanosoma congolense | TcIL3000_8_1880 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.511391.100 | Isy1-like splicing family, putative |
Toxoplasma gondii | TGME49_203870 | RAB43, member RAS oncogene family protein |
Theileria parva | TP02_0783 | hypothetical protein |
Trichomonas vaginalis | TVAG_178720 | cell cycle control protein cwf12, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.1930 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.1930 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.1930 | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb927.8.1930 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F53B7.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F53B7.3 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_F53B7.3 | Caenorhabditis elegans | sterile | wormbase |
TGME49_203870 | Toxoplasma gondii | Probably essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.